摘要

联动成像技术（LCI）是一种新型的图像增强内镜技术，强调黏膜的色差，有研究表明其在早期胃癌和结肠癌检测中的实用性。然而，LCI是否有助于巴雷特腺癌（BA）的诊断尚不清楚。在这项研究中，我们探讨了LCI是否会增强BA病变与周围黏膜之间的色差。方法回顾性分析2014年11月至2017年9月期间接受内镜黏膜下剥离术的20例浅表性BA患者的21个病灶。根据国际照明委员会（CIE）实验室颜色系统，采用白光成像（WLI）、蓝光成像（BLI）和LCI客观评价病变内部和外部的色差（ΔE*）。此外，我们还比较了病变的形态、颜色和病变周围组织。结果WLI和BLI的色差中位数（ΔE*）分别为9.1和5.8，无差异。LCI的中位色差为17.6，高于WLI和BLI。无论BA病变的形态、颜色和病变周围组织，LCI的色差均大于WLI。

Abstract: Objective Linked-color imaging (LCI), a new technology for image-enhanced endoscopy, emphasizes the color of the mucosa, and its practicality in the detection of early gastric and colon cancers has been reported. However, whether or not LCI is useful for the diagnosis of Barrett's adenocarcinoma (BA) has been unclear. In this study, we explored whether or not LCI enhances the color difference between a BA lesion and the surrounding mucosa. Methods Twenty-one lesions from 20 consecutive patients with superficial BA who underwent endoscopic submucosal dissection between November 2014 and September 2017 were retrospectively examined. The color differences (ΔE*) between the inside and outside of the lesion were evaluated retrospectively using white-light imaging (WLI), blue-light imaging (BLI), and LCI objectively, based on a Commission Internationale de l'Eclairage (CIE) lab color system. Furthermore, we compared the morphology, color, and circumferential location of the lesion. Results The median values of the color difference (ΔE*) in WLI and BLI were 9.1 and 5.8, respectively, and no difference was observed. In LCI, the median color difference was 17.6, which was higher than that of WLI and BLI. Regardless of the morphology, color, and circumferential location of BA lesions, the color difference was larger in LCI than in WLI.