方法

在前瞻性招募的患者中，先用LCI再用白光观察整个胃窦。当白光检测到白色平坦隆起（WFE）和LCI模式下薰衣草紫征（LCS）时，在LCI观察后进行目标活检。对既没有WFE也没有LCS的患者进行随机活检。主要终点是每位患者白光和LCI中GIM诊断的准确性，次要终点是GIM活检和观察者间协议的诊断准确性。

Methods: In prospectively recruited patients, the whole antrum was observed by white light imaging (WLI) followed by LCI. When a whitish flat elevation (WFE) in WLI and a lavender color sign (LCS) in LCI were detected, target biopsies were performed after LCI. Random biopsies were performed in patients who had neither WFE nor LCS. The primary endpoint was the diagnostic accuracy of GIM per patient in WLI and LCI and the secondary endpoints were that of GIM per biopsy and interobserver agreement.

结果

分析了128位患者的数据，其中58名患者（45.3%）在胃窦有组织学GIM。白光和LCI检测GIM的患者收益分别为19.0%（11/58）和91.4%（53/58）。GIM目标组织活检的诊断准确性在白光中为23.7%，在LCI中为84.2%。3位医生的Kappa值分别为WFE 0.6、LCS 0.78。

Results: Data from 128 patients were analyzed and 58 patients (45.3%) had histological GIM in the antrum. The per-patient yields of WLI and LCI to detect GIM were 19.0% (11/58) and 91.4% (53/58) respectively. Diagnostic accuracies of target biopsies for GIM were 23.7% in WLI and 84.2% in LCI. Kappa values among 3 doctors were 0.60 for WFE and 0.78 for LCS respectively.