方法

前瞻性纳入接受食管胃十二指肠镜检查的患者。图像收集过程是随机和匿名的，5位审阅者分开评估4张白光图像或4张LCI图像。活动性胃炎阳性定义为白光下呈弥漫性发红且LCI模式下呈深红色。幽门螺杆菌的感染状态由尿素呼气试验和血清抗体试验确定。两项检测结果均为阴性但组织学证实有萎缩或肠化生的病例定义为幽门螺杆菌既往感染。主要终点是白光和LCI的诊断准确性，次要终点是评分者间的一致性。

Methods:Patients who underwent esophagogastroduodenoscopy were prospectively included. The image collection process was randomized and anonymous, and the image set included 4 images with WLI or 4 images with LCI in the corpus that 5 reviewers separately evaluated. Active gastritis was defined as positive when there was diffuse redness in WLI and crimson coloring in LCI. The H. pylori infection status was determined by the urea breath test and the serum antibody test. Cases in which both test results were negative but atrophy or intestinal metaplasia was histologically confirmed were defined as past infections. The primary endpoint was the diagnostic accuracies of WLI and LCI, and the secondary endpoint was inter-observer agreement.

结果

分析了127名患者的数据。活动性胃炎的内镜诊断白光的准确度为79.5（敏感性84.4和特异性74.6），LCI是86.6（敏感性84.4和特异性88.9）（p=0.029）。与白光相比，LCI显著提高了幽门螺杆菌既往感染患者的准确性（白光为36.8，LCI为78.9，p＜0.01）。K值在白光中为0.59，在LCI中为0.70。

Results:Data for 127 patients were analyzed. The endoscopic diagnostic accuracy for active gastritis was 79.5 (sensitivity of 84.4 and specificity of 74.6) with WLI and 86.6 (sensitivity of 84.4 and specificity of 88.9) with LCI (p = 0.029). LCI significantly improved the accuracy in patients with past infections over WLI (36.8 in WLI and 78.9 in LCI, p < 0.01). The κ values were 0.59 in WLI and 0.70 in LCI.